B-1 is intimately involved in many aspects of nerve health and function. The active co-enzyme form of B-1, thiamin pyrophosphate (TPP), is necessary for energy production and is essential for the formation of acetylcholine, a major neurotransmitter. Magnesium plays a role in neuromuscular transmission and activity, promoting muscle relaxation. A highly processed "junk food" diet, excessive alcohol intake, and exhaustive exercise may increase the need for B-1.